PUBLISHED RESEARCH


Kaplan LM, McCallum R, Koch K, Sederman R, Henderson B. High Prevalence and Underdiagnosis of Gastroparesis Symptoms Among Patients with Type 1 and Type 2 Diabetes Mellitus. Digestive Disease Week, May 20, 2013.

Shin A, Camilleri M, Busciglio I, Burton D, Smith SA, Vella A, Ryks M, Rhoten D, Zinsmeister AR. Phase 1, Randomized, Placebo-Controlled, Single-Dose, Two-Period, Crossover Study of RM-131 on Pharmacodynamics and Symptoms in Type 1 Diabetics with Documented Delayed Gastric Emptying. Digestive Disease Week, May 20, 2013.

Shin A, Camilleri M, Busciglio I, Burton D, Smith SA, Vella A, Ryks M, Rhoten D, Zinsmeister AR. The Ghrelin Agonist RM-131 Accelerates Gastric Emptying of Solids and Reduces Symptoms in Patients with Type 1 Diabetes Mellitus. Clin Gastroenterol Hepatol. 2013 Apr 29 [Epub ahead of print]. PubMed PMID: 23639598. doi: 10.1016/j.cgh.2013.04.019.

Kievit P, Halem H, Marks DL, Dong JZ, Glavas MM, Sinnayah P, Pranger L, Cowley MA, Grove KL, Culler MD. Chronic Treatment With a Melanocortin 4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques. Diabetes. 2012 Oct 9 [Epub ahead of print]. doi:10.2337/db12-0598.

Shin A, Camilleri M, Busciglio I, Burton D, Stoner E, Noonan P, Gottesdiener K, Smith SA, Vella A, Zinsmeister AR. Randomized Controlled Phase Ib Study of Ghrelin Agonist, RM-131, in Type 2 Diabetic Women With Delayed Gastric Emptying: Pharmacokinetics and pharmacodynamics. Diabetes Care. 2012 Sep 6 [Epub ahead of print]. PubMed PMID: 22961573. doi: 10.2337/dc12-1128.

Datta R, Soulard C, Teillot M, Touvay C, Halem H, Dong J, Culler M. RM-131: A Potent Gastroprokinetic Agent. Digestive Disease Week, May 7, 2011.

Roubert P, Dubern B, Plas P, Lubrano-Berthelier C, Alihi R, Auger F, Deoliveira D, Dong J, Basdevant A, Thurieau C, Cle┬┤ment K. Novel Pharmacological MC4R Agonists can Efficiently Activate Mutated MC4R from Obese Patient with Impaired Endogenous Agonist Response. J Endocrinol. (2010) 207, 177-183.