Pioneering a path forward at Rhythm

Our mission

To transform the lives of patients with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause.

Our vision

Patients with rare neuroendocrine diseases are able to live their fullest lives and are transformed through optimal, stigma-free care.

It takes great people to make a great company

It’s the people that make Rhythm so special.

Our path to transforming the care of rare melanocortin-4 receptor (MC4R) pathway diseases

2008

Founded in Boston

2016

Phase 2 results in POMC deficiency published in the New England Journal of Medicine

2018

Phase 2 results in LEPR deficiency published in Nature Medicine

2020

FDA approves IMCIVREE for obesity due to POMC and LEPR deficiency

2022

IMCIVREE approved for BBS in US and Europe

2024

First-ever patients dosed with RM-718

Acquired oral MC4R agonist LB54640 from LG Chem Life Sciences

2011

First patients dosed with setmelanotide

2017

Initial Public Offering completed on Nasdaq

2019

Phase 3 trial in POMC deficiency initiated

2021

European Commission authorizes IMCIVREE for obesity due to POMC and LEPR deficiency

2023

Acquires Xinvento

Initiates Phase 3 trial in acquired hypothalamic obesity

2008

Founded in Boston

2011

First patients dosed with setmelanotide

2016

Phase 2 results in POMC deficiency published in the New England Journal of Medicine

2017

Initial Public Offering completed on Nasdaq

2018

Phase 2 results in LEPR deficiency published in Nature Medicine

2019

Phase 3 trial in POMC deficiency initiated

2020

FDA approves IMCIVREE for obesity due to POMC and LEPR deficiency

2021

European Commission authorizes IMCIVREE for obesity due to POMC and LEPR deficiency

2022

IMCIVREE approved for BBS in US and Europe

2023

Acquires Xinvento

Initiates Phase 3 trial in hypothalamic obesity

2024

First-ever patients dosed with RM-718

Acquired oral MC4R agonist LB54640 from LG Chem Life Sciences

Our story

Rhythm was founded in 2008 in Boston.

Our lead asset, IMCIVREE® (setmelanotide), FDA-approved in 2020, is a precision medicine designed to treat severe obesity caused by an impairment of a pathway in the hypothalamus called the MC4R pathway.

Rhythm became a publicly traded company in 2017. Now, we have grown to more than 250 employees in North America and Europe. With a robust clinical trials program, we remain poised for even more growth in the near future. As we continue to grow, the one thing that will never change is our commitment to patients.

Our leadership team is passionate about developing new therapies for patients.

Our employees strive every day to pioneer a path forward for patients and families living with rare neuroendocrine diseases.